Condensed Consolidated Statements of Shareholders' Equity - USD ($) $ in Thousands	Total	Common Shares [Member]	Treasury Shares [Member]	Additional Paid-in Capital [Member]	Retained Earnings (Deficit) [Member]	Accumulated Other Comprehensive Income (Loss) [Member]
Beginning balance at Dec. 31, 2020	$ 1,664,234	$ 2,277	$ (63)	$ 2,235,679	$ (573,576)	$ (83)
Beginning balance (in shares) at Dec. 31, 2020		73,914,844	195,316
Issuance of common shares, net of issuance costs	222,175	$ 45		222,130
Issuance of common shares, net of issuance costs (in shares)		1,353,121
Vesting of restricted shares	3	$ 3
Vesting of restricted shares (in shares)		109,355
Exercise of vested options, net of issuance costs, value	9,784	$ 15		9,769
Exercise of vested options, net of issuance costs (in shares)		342,051
Purchase of common stock under ESPP	751			751
Purchase of common stock under ESPP (in shares)		11,257
Stock-based compensation expense	22,092			22,092
Other comprehensive loss	(378)					(378)
Net (loss) income	(113,163)				(113,163)
Ending balance at Mar. 31, 2021	1,805,498	$ 2,340	$ (63)	2,490,421	(686,739)	(461)
Ending balance (in shares) at Mar. 31, 2021		75,730,628	195,316
Beginning balance at Dec. 31, 2020	1,664,234	$ 2,277	$ (63)	2,235,679	(573,576)	(83)
Beginning balance (in shares) at Dec. 31, 2020		73,914,844	195,316
Net (loss) income	518,909
Ending balance at Sep. 30, 2021	2,512,923	$ 2,366	$ (63)	2,566,057	(54,667)	(770)
Ending balance (in shares) at Sep. 30, 2021		76,463,180	180,316
Beginning balance at Mar. 31, 2021	1,805,498	$ 2,340	$ (63)	2,490,421	(686,739)	(461)
Beginning balance (in shares) at Mar. 31, 2021		75,730,628	195,316
Vesting of restricted shares (in shares)		3,667
Exercise of vested options, net of issuance costs, value	10,909	$ 12		10,897
Exercise of vested options, net of issuance costs (in shares)		344,158
Stock-based compensation expense	28,331			28,331
Other comprehensive loss	(168)					(168)
Net (loss) income	759,225				759,225
Ending balance at Jun. 30, 2021	2,603,795	$ 2,352	$ (63)	2,529,649	72,486	(629)
Ending balance (in shares) at Jun. 30, 2021		76,078,453	195,316
Vesting of restricted shares	4	$ 4
Vesting of restricted shares (in shares)		96,167
Exercise of vested options, net of issuance costs, value	8,875	$ 10		8,865
Exercise of vested options, net of issuance costs (in shares)		278,227	(15,000)
Purchase of common stock under ESPP	1,344			1,344
Purchase of common stock under ESPP (in shares)		10,333
Stock-based compensation expense	26,199			26,199
Other comprehensive loss	(141)					(141)
Net (loss) income	(127,153)				(127,153)
Ending balance at Sep. 30, 2021	2,512,923	$ 2,366	$ (63)	2,566,057	(54,667)	(770)
Ending balance (in shares) at Sep. 30, 2021		76,463,180	180,316
Beginning balance at Dec. 31, 2021	2,399,460	$ 2,391	$ (63)	2,598,114	(195,915)	(5,067)
Beginning balance (in shares) at Dec. 31, 2021		76,990,066	180,316
Vesting of restricted shares	4	$ 4
Vesting of restricted shares (in shares)		123,564
Exercise of vested options, net of issuance costs, value	10,010	$ 12		9,998
Exercise of vested options, net of issuance costs (in shares)		261,280
Purchase of common stock under ESPP	740			740
Purchase of common stock under ESPP (in shares)		11,495
Stock-based compensation expense	25,745			25,745
Other comprehensive loss	(11,826)					(11,826)
Net (loss) income	(179,217)				(179,217)
Ending balance at Mar. 31, 2022	2,244,916	$ 2,407	$ (63)	2,634,597	(375,132)	(16,893)
Ending balance (in shares) at Mar. 31, 2022		77,386,405	180,316
Beginning balance at Dec. 31, 2021	$ 2,399,460	$ 2,391	$ (63)	2,598,114	(195,915)	(5,067)
Beginning balance (in shares) at Dec. 31, 2021		76,990,066	180,316
Exercise of vested options, net of issuance costs (in shares)	1,053,443
Net (loss) income	$ (539,600)
Ending balance at Sep. 30, 2022	1,953,954	$ 2,433	$ (63)	2,709,361	(735,515)	(22,262)
Ending balance (in shares) at Sep. 30, 2022		78,247,830	180,316
Beginning balance at Mar. 31, 2022	2,244,916	$ 2,407	$ (63)	2,634,597	(375,132)	(16,893)
Beginning balance (in shares) at Mar. 31, 2022		77,386,405	180,316
Vesting of restricted shares (in shares)		14,705
Exercise of vested options, net of issuance costs, value	10,346	$ 13		10,333
Exercise of vested options, net of issuance costs (in shares)		391,053
Stock-based compensation expense	24,852			24,852
Other comprehensive loss	(3,449)					(3,449)
Net (loss) income	(185,834)				(185,834)
Ending balance at Jun. 30, 2022	2,090,831	$ 2,420	$ (63)	2,669,782	(560,966)	(20,342)
Ending balance (in shares) at Jun. 30, 2022		77,792,163	180,316
Issuance of common shares, net of issuance costs	970			970
Issuance of common shares, net of issuance costs (in shares)		12,365
Vesting of restricted shares	1	$ 1
Vesting of restricted shares (in shares)		17,128
Exercise of vested options, net of issuance costs, value	12,782	$ 12		12,770
Exercise of vested options, net of issuance costs (in shares)		401,110
Purchase of common stock under ESPP	1,296			1,296
Purchase of common stock under ESPP (in shares)		25,064
Stock-based compensation expense	24,543			24,543
Other comprehensive loss	(1,920)					(1,920)
Net (loss) income	(174,549)				(174,549)
Ending balance at Sep. 30, 2022	$ 1,953,954	$ 2,433	$ (63)	$ 2,709,361	$ (735,515)	$ (22,262)
Ending balance (in shares) at Sep. 30, 2022		78,247,830	180,316