Accrued Expenses - Schedule of Accrued Expenses (Detail) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Accrued Liabilities, Current [Abstract]
Payroll and employee-related costs	$ 18,906	$ 23,661
Research costs	69,485	47,986
Licensing fees	1,239	138
Professional fees	4,834	4,720
Intellectual property costs	3,790	6,120
Accrued property and equipment	3,966	7,113
Other	734	1,265
Total	$ 102,954	$ 91,003