Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Operating activities:
Net (loss) income	$ (365,051)	$ 646,062
Reconciliation of net (loss) income to net cash used in operating activities:
Depreciation and amortization	13,308	6,368
Equity-based compensation	50,597	50,423
Other non-cash items, net	9,671	4,417
Changes in:
Accounts receivable	239	(6)
Prepaid expenses and other assets	2,032	(9,470)
Accounts payable and accrued expenses	8,303	13,427
Deferred revenue	(1,011)	(271)
Operating lease assets and liabilities	5,865	1,259
Other liabilities, net	(1,148)	(5,870)
Net cash used in operating activities	(277,195)	706,339
Investing activities:
Purchase of property, plant and equipment	(24,980)	(35,473)
Purchases of marketable securities	(597,136)	(715,982)
Maturities of marketable securities	451,529	289,921
Net cash used in investing activities	(170,587)	(461,534)
Financing activities:
Proceeds from issuance of common shares, net of issuance costs	0	213,267
Proceeds from exercise of options and ESPP contributions, net of issuance costs	21,002	21,167
Net cash provided by financing activities	21,002	234,434
Effect of exchange rate changes on cash	(95)	10
(Decrease) increase in cash	(426,875)	479,249
Cash, cash equivalents and restricted cash, beginning of period	939,944	1,185,468
Cash, cash equivalents and restricted cash, end of period	513,069	1,664,717
Supplemental disclosure of non-cash investing and financing activities
Property and equipment purchases in accounts payable and accrued expenses	5,016	7,533
Equity issuance costs in accounts payable and accrued expenses	241	$ 402
Leasehold improvements paid directly by landlord	$ 19,252