Accrued Expenses - Schedule of Accrued Expenses (Detail) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Accrued Liabilities, Current [Abstract]
Payroll and employee-related costs	$ 13,906	$ 23,661
Research costs	52,409	47,986
Licensing fees	177	138
Professional fees	4,266	4,720
Intellectual property costs	4,634	6,120
Accrued property and equipment	4,353	7,113
Other	2,478	1,265
Total	$ 82,223	$ 91,003