Net (Loss) Income Per Share Attributable to Common Shareholders (Tables)

6 Months Ended

Jun. 30, 2022

Earnings Per Share [Abstract]

Schedule of Computation of Basic and Diluted Net Income (Loss) per Share

The following table sets forth the computation of basic and diluted net (loss) income per share for the periods indicated (in thousands, except for share and per share amounts):
 

	Three Months Ended June 30,					Six Months Ended June 30,
	2022			2021		2022			2021
Net (loss) income	$	(185,834	)	$	759,225	$	(365,051	)	$	646,062
Basic weighted-average common shares outstanding		77,513,327			75,826,594		77,306,970			75,418,160
Effect of potentially dilutive securities:
Outstanding options		—			4,149,901		—			4,519,827
Unvested restricted common shares		—			473,461		—			520,868
Diluted weighted-average common shares outstanding		77,513,327			80,449,956		77,306,970			80,458,855
Basic net (loss) income per common share		(2.40	)		10.01		(4.72	)		8.57
Diluted net (loss) income per common share		(2.40	)		9.44		(4.72	)		8.03

Schedule of Antidilutive Securities not Include in Computation of Net (Loss) Income per Share

The following common stock equivalents were excluded from the calculation of diluted net (loss) income per share for the periods indicated because including them would have had an anti-dilutive effect (in thousands):

	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
Outstanding options		7,801,649		1,936,503		7,801,649		1,483,205
Unvested restricted common shares		1,085,869		385,550		1,085,869		203,335
ESPP		24,947		10,594		24,947		7,946
Total		8,912,465		2,332,647		8,912,465		1,694,486