Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 496,893	$ 923,031
Marketable securities	1,568,446	1,456,098
Accounts receivable	66	305
Prepaid expenses and other current assets	41,651	38,079
Total current assets	2,107,056	2,417,513
Property and equipment, net	165,194	137,575
Marketable securities, non-current	8,392	0
Intangible assets, net	98	125
Restricted cash	12,123	16,913
Operating lease assets	166,740	174,460
Other non-current assets	3,760	5,291
Total assets	2,463,363	2,751,877
Current liabilities:
Accounts payable	25,244	14,816
Accrued expenses	82,223	91,003
Deferred revenue, current		1,011
Accrued tax liabilities	3,953	724
Operating lease liabilities	8,267	12,158
Other current liabilities	270	171
Total current liabilities	119,957	119,883
Deferred revenue, non-current	12,323	12,323
Operating lease liabilities, net of current portion	234,160	212,872
Other non-current liabilities	6,092	7,339
Total liabilities	372,532	352,417
Commitments and contingencies, see Note 6
Shareholders’ equity:
Common shares, CHF 0.03 par value, 150,347,467 and 145,364,335 shares authorized at June 30, 2022 and December 31, 2021, respectively, 77,972,479 and 77,170,382 shares issued at June 30, 2022 and December 31, 2021, respectively, 77,792,163 and 76,990,066 shares outstanding at June 30, 2022 and December 31, 2021, respectively	2,420	2,391
Treasury shares, at cost, 180,316 shares at June 30, 2022 and at December 31, 2021	(63)	(63)
Additional paid-in capital	2,669,782	2,598,114
Accumulated deficit	(560,966)	(195,915)
Accumulated other comprehensive loss	(20,342)	(5,067)
Total shareholders' equity	2,090,831	2,399,460
Total liabilities and shareholders’ equity	$ 2,463,363	$ 2,751,877