Commitments and Contingencies - Additional Information (Detail) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021	Mar. 31, 2021
Contingencies And Commitments [Line Items]
Operating lease, right-of-use asset	$ 171,541	$ 174,460
Restricted cash	12,123	$ 16,913	$ 16,844
Prepaid Expenses and Other Current Assets [Member]
Contingencies And Commitments [Line Items]
Letters of credit secured by cash held in restricted depository account	4,783
Prepaid expenses and other current assets	4,783
Restricted cash	4,783
Letter of Credit [Member]
Contingencies And Commitments [Line Items]
Letters of credit secured by cash held in restricted depository account	16,900
Prepaid expenses and other current assets	16,900
Restricted cash	16,900
Letter of Credit [Member] | Prepaid Expenses and Other Current Assets [Member]
Contingencies And Commitments [Line Items]
Letters of credit secured by cash held in restricted depository account	4,800
Prepaid expenses and other current assets	4,800
Restricted cash	4,800
Letter of Credit [Member] | Restricted Cash Noncurrent [Member]
Contingencies And Commitments [Line Items]
Letters of credit secured by cash held in restricted depository account	12,100
Prepaid expenses and other current assets	12,100
Restricted cash	12,100
2015 Collaboration Agreement [Member] | Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member]
Contingencies And Commitments [Line Items]
Milestone payment receivable	$ 395,000