Accrued Expenses - Schedule of Accrued Expenses (Detail) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Accrued Liabilities, Current [Abstract]
Payroll and employee-related costs	$ 8,780	$ 23,661
Research costs	49,925	47,986
Licensing fees	533	138
Professional fees	4,456	4,720
Intellectual property costs	4,345	6,120
Accrued property and equipment	2,321	7,113
Other	2,272	1,265
Total	$ 72,632	$ 91,003