Accrued Expenses - Schedule of Accrued Expenses (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Accrued Liabilities, Current [Abstract]
Payroll and employee-related costs	$ 23,661	$ 22,402
Research costs	47,986	21,684
Licensing fees	138	1,401
Professional fees	4,720	1,670
Intellectual property costs	6,120	3,625
Accrued property and equipment	7,113	2,835
Other	1,265	165
Total	$ 91,003	$ 53,782