Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 923,031	$ 1,168,620
Marketable securities	1,456,098	521,713
Accounts receivable	305	144
Prepaid expenses and other current assets	38,079	26,143
Total current assets	2,417,513	1,716,620
Property and equipment, net	137,575	42,160
Intangible assets, net	125	180
Restricted cash	16,913	16,848
Operating lease assets	174,460	50,865
Other non-current assets	5,291	1,293
Total assets	2,751,877	1,827,966
Current liabilities:
Accounts payable	14,816	9,094
Accrued expenses	91,003	53,782
Deferred revenue, current	1,011	2,341
Accrued tax liabilities	724	10,473
Operating lease liabilities	12,158	11,362
Other current liabilities	171	7,207
Total current liabilities	119,883	94,259
Deferred revenue, non-current	12,323	11,776
Operating lease liabilities, net of current portion	212,872	50,067
Other non-current liabilities	7,339	7,630
Total liabilities	352,417	163,732
Commitments and contingencies (Note 8)
Shareholders’ equity:
Common shares, CHF 0.03 par value, 145,364,335 and 115,172,786 shares authorized at December 31, 2021 and 2020, respectively, 77,170,164 and 74,110,160 shares issued at December 31, 2021 and 2020, respectively 76,989,848 and 73,914,844 shares outstanding at December 31, 2021 and 2020, respectively	2,391	2,277
Treasury shares, at cost, 180,316 and 195,316 shares at December 31, 2021 and 2020, respectively	(63)	(63)
Additional paid-in capital	2,598,114	2,235,679
Accumulated deficit	(195,915)	(573,576)
Accumulated other comprehensive income (loss)	(5,067)	(83)
Total shareholders’ equity	2,399,460	1,664,234
Total liabilities and shareholders’ equity	$ 2,751,877	$ 1,827,966