X0306 4 2020-03-31 0 0001674365 Aptinyx Inc. APTX 0001553470 Gould Terry P C/O APTINYX INC. 909 DAVIS STREET, SUITE 600 EVANSTON IL 60201 1 0 1 0 Stock Option (Right to Buy) 2.16 2020-03-31 4 A 0 7374 1.356 A 2030-03-30 Common Stock 7374 7374 D The option award was issued to the Reporting Person, who elected to take equity awards in lieu of cash compensation for services as a director, pursuant to the Issuer's non-employee director compensation plan. The number of options granted was determined by dividing the cash compensation otherwise payable with respect to the quarter by the Black-Scholes value of a single option calculated as of the date of the grant. This option is fully vested at time of grant. The Reporting Person, Terry P. Gould, is a partner of Adams Street Partners, LLC ("Adams Street"). Adams Street is the direct or indirect general partner/investment adviser of managed entities that own common stock of the Issuer. By agreement with certain of such Adams Street funds, Mr. Gould is deemed to hold the stock options for the benefit of those funds. Mr. Gould disclaims beneficial ownership of the stock options except to the extent of his pecuniary interest therein. /s/ Ashish Khanna, Attorney-In-Fact 2020-04-02