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Property and equipment, net (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Dec. 31, 2021
Property and equipment          
Less accumulated depreciation $ (1,496)   $ (1,496)   $ (1,347)
Property and equipment, net 36   36   185
Depreciation   $ 100 100 $ 500  
Maximum          
Property and equipment          
Depreciation 100        
Office equipment and furniture          
Property and equipment          
Property and equipment, gross 152   152   152
Laboratory equipment          
Property and equipment          
Property and equipment, gross 401   401   401
Leasehold improvements          
Property and equipment          
Property and equipment, gross $ 979   $ 979   $ 979