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Property and equipment (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2020
Mar. 31, 2019
Dec. 31, 2019
Property and equipment      
Less accumulated depreciation $ (1,774)   $ (1,646)
Property and equipment, net 1,101   1,204
Depreciation and amortization 108 $ 117  
Computer software and equipment      
Property and equipment      
Property and equipment, gross 15   15
Office equipment and furniture      
Property and equipment      
Property and equipment, gross 176   176
Laboratory equipment      
Property and equipment      
Property and equipment, gross 1,622   1,597
Leasehold improvements      
Property and equipment      
Property and equipment, gross 1,051   1,051
Construction-in-progress      
Property and equipment      
Property and equipment, gross $ 11   $ 11