X0306 4 2020-06-30 0 0001674365 Aptinyx Inc. APTX 0001578965 Koppel Adam C/O BAIN CAPITAL LIFE SCIENCES INVESTORS LLC, 200 CLARENDON STREET BOSTON MA 02116 1 0 1 0 Stock Option (Right Buy) 4.17 2020-06-30 4 A 0 4370 2.677 A 2030-06-29 Common Stock 4370 4370 D This option is fully vested at time of grant. The option award was issued to the Reporting P erson, who elected to take equity awards in lieu of cash compensation for services as a director, pursuant to the Issuer's nonemployee director compensation plan. The number of options granted was determined by dividing the cash compensation otherwise payable with respect to the quarter by the Black-Scholes value of a single option calculated as of the date of the grant. /s/ Adam Koppel 2020-07-02