X0306 4 2022-06-06 0 0001662774 Cortexyme, Inc. CRTX 0001674232 McDowell Caryn Gordon C/O CORTEXYME, INC. 269 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Legal & Adm. Officer Common Stock 2022-06-06 4 F 0 6700 2.8632 D 133300 D Common Stock 2022-06-06 4 S 0 10800 2.8632 D 122500 D Represent shares sold to satisfy tax withholding obligations that arose in connection with the vesting of 17,500 shares of Restricted Stock Units granted on March 3, 2022. The sales were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 23, 2022. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.78 to $3.12, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. /s/ Caryn Gordon McDowell 2022-06-08