X0306 4 2019-11-11 0 0001785173 89bio, Inc. ETNB 0001713663 Longitude Capital Partners III, LLC 2740 SAND HILL RD 2ND FLOOR MENLO PARK CA 94025 0 0 1 0 0001674099 Longitude Venture Partners III, L.P. 2740 SAND HILL RD 2ND FLOOR MENLO PARK CA 94025 0 0 1 0 0001431159 Tammenoms Bakker Juliet 2740 SAND HILL RD 2ND FLOOR MENLO PARK CA 94025 0 0 1 0 0001253886 ENRIGHT PATRICK G 2740 SAND HILL RD 2ND FLOOR MENLO PARK CA 94025 0 0 1 0 Common Stock 2019-11-11 4 P 0 575000 16.00 A 575000 I See footnote Common Stock 2019-11-13 4 C 0 1916787 A 2491787 I See footnote Series A Preferred Stock 2019-11-13 4 C 0 11916667 0.00 D Common Stock 1916787 0 I See footnote On November 11, 2019, Longitude Venture Partners III, L.P. ("Longitude Venture III") purchased 575,000 shares of the Issuer's common stock at a price of $16.00 per share in the Issuer's initial public offering. The Series A Preferred Stock automatically converted into shares of the Issuer's common stock on a one-for-6.217 basis immediately prior the closing of the Issuer's initial public offering on November 13, 2019 and had no expiration date. These shares are held directly by Longitude Venture III. Longitude Capital Partners III, LLC ("Longitude Capital III") is the general partner of Longitude Venture III and may be deemed to have shared voting, investment and dispositive power with respect to these securities. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of Longitude Capital III (each a "Manager" and collectively, the "Managers") and may each be deemed to share voting, investment and dispositive power with respect to these securities. Each of Longitude Capital III and the Managers disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein. Longitude Venture Partners III, L.P.; By /s/ Patrick G. Enright, Managing Member 2019-11-13 Longitude Capital Partners III, LLC; By /s/ Patrick G. Enright, Managing Member 2019-11-13 /s/ Juliet Tammenoms Bakker 2019-11-13 /s/ Patrick G. Enright 2019-11-13