X0306 4 2016-09-30 0 0001638287 Gemphire Therapeutics Inc. GEMP 0001674006 Sooch Mina 17199 N. LAUREL PARK DRIVE SUITE 401 LIVONIA MI 48152 1 1 0 0 President & CEO Employee Stock Option (right to buy) 10 2016-09-30 4 A 0 120000 0 A 2026-08-03 Common Stock 120000 480000 D The reporting person was granted an option to purchase 600,000 shares of common stock effective August 4, 2016. 360,000 of the shares underlying the option award were immediately earned on the date of grant, 120,000 shares underlying the option award are earned upon the initiation of the Company's first clinical trial and 120,000 shares underlying the option award are earned upon the initiation of the Company's second clinical trial. The Company has initiated its first clinical trial, so the 120,000 shares underlying the option award that were subject to the initiation of the Company's first clinical trial have been earned. The option vests in 48 equal consecutive monthly increments, so that all of the shares will be vested on the fourth anniversary of the date of grant. Stephanie Swan, by Power of Attorney 2016-10-03