X0306 4/A 2020-03-24 2020-03-26 0 0001571498 Epizyme, Inc. EPZM 0001673802 Ros Matthew C/O EPIZYME, INC., 400 TECHNOLOGY SQUARE CAMBRIDGE MA 02139 0 1 0 0 See Remarks Common Stock, par value $0.0001 2020-03-24 4 A 0 4000 A 54235 D The Form 4 originally filed on March 26, 2020 inadvertently reported an incorrect amount of shares of common stock issued to the reporting person upon vesting of restricted stock units granted under the issuer's 2013 Stock Incentive Plan. Chief Strategy & Business Officer /s/ John Weidenbruch, attorney-in-fact 2020-06-29