X0508 4 2024-01-06 0 0001370053 ANAPTYSBIO, INC ANAB 0001673528 Faga Daniel C/O ANAPTYSBIO, INC. 10770 WATERIDGE CIRCLE, SUITE 210 SAN DIEGO CA 92121 1 1 0 0 CEO 0 Common Stock 2024-01-06 4 M 0 17850 0.00 A 904893 D Common Stock 2024-01-08 4 S 0 6866 21.81 D 898027 D Restricted Stock Unit 2024-01-06 4 M 0 17850 0.00 D Common Stock 17850 53550 D Each restricted stock award ("RSU") represents a contingent right to receive 1 share of the Issuer's Common Stock upon settlement for no consideration. Certain of the shares are subject to forfeiture to the Issuer if underlying vesting conditions are not met. The sale reported on this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the Reporting Person. The RSUs vests as to 25% of the total RSUs annually commencing on January 6, 2024 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date. /s/ Eric Loumeau, Attorney-in-Fact 2024-01-09