<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2016-06-26</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001082554</issuerCik>
        <issuerName>UNITED THERAPEUTICS Corp</issuerName>
        <issuerTradingSymbol>UTHR</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001673232</rptOwnerCik>
            <rptOwnerName>BENKOWITZ MICHAEL</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O UNITED THERAPEUTICS CORPORATION</rptOwnerStreet1>
            <rptOwnerStreet2>1040 SPRING STREET</rptOwnerStreet2>
            <rptOwnerCity>SILVER SPRING</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20910</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>1</isOfficer>
            <officerTitle>President and COO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1088</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Share Tracking Award</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>53.83</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2018-01-02</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2023-01-02</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>100000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Share Tracking Award</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>163.30</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2016-03-13</value>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2025-03-13</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>37200</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Share Tracking Award</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>94.96</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2015-03-14</value>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <value>2024-03-14</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>40000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Share Tracking Award</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>47.50</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2013-03-15</value>
                <footnoteId id="F4"/>
            </exerciseDate>
            <expirationDate>
                <value>2022-03-15</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>6450</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Share Tracking Award</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>61.06</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2014-03-15</value>
                <footnoteId id="F5"/>
            </exerciseDate>
            <expirationDate>
                <value>2023-03-15</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>18400</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Options</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>120.26</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2017-03-15</value>
                <footnoteId id="F6"/>
            </exerciseDate>
            <expirationDate>
                <value>2026-03-15</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>39200</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Share Tracking Award</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>68.14</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2012-04-04</value>
                <footnoteId id="F7"/>
            </exerciseDate>
            <expirationDate>
                <value>2021-04-04</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>21750</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">These share tracking awards cliff vest on January 2, 2018, and settle in cash only.</footnote>
        <footnote id="F2">These share tracking awards vest in one-fourth increments on each of March 13, 2016, 2017, 2018 and 2019, and settle in cash only.</footnote>
        <footnote id="F3">These share tracking awards vest in one-fourth increments on each of March 14, 2015, 2016, 2017 and 2018, and settle in cash only. Of the outstanding awards, 20,000 are vested as of the date of this filing.</footnote>
        <footnote id="F4">These share tracking awards vested in one-fourth increments on each of March 15, 2013, 2014, 2015 and 2016, and settle in cash only. All of the remaining awards are fully vested.</footnote>
        <footnote id="F5">These share tracking awards vest in one-fourth increments on each of March 15, 2014, 2015, 2016 and 2017, and settle in cash only. Of the outstanding awards, 9,200 are vested as of the date of this filing, and the remaining 9,200 are expected to vest on March 15, 2017.</footnote>
        <footnote id="F6">These stock options vest in one-fourth increments on each of March 15, 2017, 2018, 2019 and 2020.</footnote>
        <footnote id="F7">These share tracking awards vested in one-fourth increments on each of April 4, 2012, 2013, 2014 and 2015, and settle in cash only. All remaining awards are fully vested.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ John S. Hess, Jr. under Power of Attorney</signatureName>
        <signatureDate>2016-06-27</signatureDate>
    </ownerSignature>
</ownershipDocument>
