0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - STATEMENTS OF CHANGES IN STOCKHOLDERS’ EQUITY link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - STATEMENTS OF CHANGES IN STOCKHOLDERS’ EQUITY (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 9952156 - Disclosure - Organization and nature of operations link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Summary of significant accounting policies link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Revenue recognition link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Collaborative arrangements link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Investments link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Fair value measurements link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Property and equipment, net link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Intangibles, net link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Accounts payable and accrued expenses link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Commitments and contingencies link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Common stock link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Stock-based compensation link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Employee benefit plans link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Net loss per share link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Segment reporting link:presentationLink link:calculationLink link:definitionLink 9952172 - Disclosure - Income taxes link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of significant accounting policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Investments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Fair value measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Property and equipment, net (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Intangibles, net (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Accounts payable and accrued expenses (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Stock-based compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Net loss per share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Segment reporting (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Income taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Summary of significant accounting policies - Property and Equipment, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Revenue recognition (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Collaborative arrangements (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Investments - Amortized and Fair Value of our Investments (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Investments - Narratives (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Fair value measurements - Assets and Liabilities Measured on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Fair value measurements - Narratives (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Property and equipment, net - Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Property and equipment, net - Narratives (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Intangibles, net - Narratives (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Intangibles, net - Finite-Lived Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Goodwill and intangibles, net - Schedule of Weighted-Average (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Intangibles, net - Finite-Lived Intangible Assets, Future Amortization Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Accounts payable and accrued expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Leases - Narratives (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Leases - Components of Lease Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Leases - Future Undiscounted Lease Payments (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Leases - Future Undiscounted Lease Payments (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Leases - Weighted Average Remaining Lease Term and Discount Rate (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Commitments and contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Common stock (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Stock-based compensation - Narratives (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Stock-based compensation - Allocated Share-based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Stock-based compensation - Stock Option Rollforward (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Stock-based compensation - Determination of Fair Value (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Stock-based compensation - Restricted Stock (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Employee benefit plans (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Net loss per share - Anti-dilutive Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Segment reporting - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Segment reporting - Segment Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Income taxes - Benefit from (Provision for) Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Income taxes - Income (loss) Before Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Income taxes - Reconciliation of Income Tax Rate to Effective Tax Rate (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Income Taxes - U.S. Federal Statutory Income Tax Rate (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Income taxes - Components Deferred Income Tax Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Income Taxes - Narratives (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Income taxes - Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink