<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001873003</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>4</amendmentNo>
      <securitiesClassTitle>Common stock, par value, $0.0001 per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>09/30/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001672688</issuerCik>
        <issuerName>Absci Corporation</issuerName>
        <issuerCusip>00091E109</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>18105 SE Mill Plain Boulevard</com:street1>
          <com:city>Vancouver</com:city>
          <com:stateOrCountry>WA</com:stateOrCountry>
          <com:zipCode>98683</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(d)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Sean McClain</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>11002709.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>8723173.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>11002709.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>7.2</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
      <comments>(5)Consists of (i) 6,456,420 shares of common stock held of record by Sean McClain (the "Reporting Person"), (ii) 2,269,987 shares of common stock held by Brittany McClain, which shares are subject to a voting agreement and proxy pursuant to which the Reporting Person is entitled to vote such shares on all matters presented to the Issuer's stockholders for approval, (iii) 2,266,753 shares of common stock subject to options exercisable by the Reporting Person within 60 days of September 30, 2025, and (iv) 9,549 shares of common stock subject to options exercisable by Brittany McClain within 60 days of September 30, 2025, which are subject to a voting agreement proxy pursuant to which the Reporting Person is entitled to vote such shares on all matters presented to the Issuer's stockholders for approval.
(7)Consists of (i) 6,456,420 shares of common stock held of record by the Reporting Person and (ii) 2,266,753 shares of common stock subject to options exercisable within 60 days of September 30, 2025.
(11)Based on the quotient obtained by dividing (a) the aggregate amount beneficially owned by the Reporting Person as set forth in Row 9 by (b) the sum of (i) 149,746,035 shares of common stock outstanding as of September 30, 2025 and (ii) 2,276,302 shares of common stock subject to options exercisable within 60 days of September 30, 2025.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Absci Corporation</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>18105 SE Mill Plain Boulevard, Vancouver, WA, 98683</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Sean McClain</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>c/o Absci Corporation
18105 SE Mill Plain Boulevard
Vancouver, WA 98683</principalBusinessOfficeOrResidenceAddress>
        <citizenship>United States</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>11,002,709</amountBeneficiallyOwned>
        <classPercent>7.2</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>11,002,709
Consists of (i) 6,456,420 shares of common stock held of record by Sean McClain (the "Reporting Person"), (ii) 2,269,987 shares of common stock held by Brittany McClain, which shares are subject to a voting agreement and proxy pursuant to which the Reporting Person is entitled to vote such shares on all matters presented to the Issuer's stockholders for approval, (iii) 2,266,753 shares of common stock subject to options exercisable by the Reporting Person within 60 days of September 30, 2025, and (iv) 9,549 shares of common stock subject to options exercisable by Brittany McClain within 60 days of September 30, 2025, which are subject to a voting agreement proxy pursuant to which the Reporting Person is entitled to vote such shares on all matters presented to the Issuer's stockholders for approval.</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>8,723,173
Consists of (i) 6,456,420 shares of common stock held of record by the Reporting Person and (ii) 2,266,753 shares of common stock subject to options exercisable within 60 days of September 30, 2025.</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
        <classOwnership5PercentOrLess>N</classOwnership5PercentOrLess>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>Sean McClain</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Shelby Walker</signature>
        <title>Shelby Walker, Attorney-in-fact for Sean McClain</title>
        <date>11/13/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
