144 0001967150 XXXXXXXX LIVE 0001672619 Enliven Therapeutics, Inc. 001-39247 6200 LOOKOUT ROAD BOULDER CO 80301 720-647-8519 Lyssikatos Joseph P Officer Common Jefferies LLC

520 Madison Ave 4th Fl New York NY 10022

12500 249125.00 59000000 09/19/2025 Nasdaq Common 09/01/2019 Founder shares Enliven Therapeutics N 12500 09/01/2019 N/A N Joseph Lyssikatos

6200 Lookout Rd 1st Fl Boulder CO 80301

Enliven Therapeutics Inc 07/21/2025 12000 278646.38 Joseph Lyssikatos

6200 Lookout Rd 1st Fl Boulder CO 80301

Enliven Therapeutics Inc 08/19/2025 5000 98117.55 Joseph Lyssikatos

6200 Lookout Rd 1st Fl Boulder CO 80301

Enliven Therapeutics Inc 08/21/2025 7500 150099.08 All sales are to be made pursuant to a previously signed/adopted 10b5-1 selling plan dated 11/15/2024, and all representations regarding material non-public information were made as of the adoption of the plan. The shares in this filing will be sold from The Lyssikatos Revocable Trust UAD 12/15/11. 09/19/2025 11/15/2024 Joseph Lyssikatos