X0306 4 2021-06-29 0 0001672619 IMARA Inc. IMRA 0001572451 Bonita David P C/O IMARA INC. 116 HUNTINGTON AVE, SIXTH FLOOR BOSTON MA 02116 1 0 1 0 Common Stock 2532402 I By OrbiMed Private Investments VII, LP Stock Option (right to buy) 8.12 2021-06-29 4 A 0 7728 0.00 A 2031-06-28 Common Stock 7728 7728 D The securities are held by OrbiMed Private Investments VII, LP, or OPI VII. OrbiMed Capital GP VII LLC, or OrbiMed GP, is the general partner of OPI VII and OrbiMed Advisors LLC, or OrbiMed Advisors, is the managing member of OrbiMed GP. As a result, OrbiMed Advisors and OrbiMed GP share power to direct the vote and disposition of the shares held by OPI VII and may be deemed to be the beneficial owners of the shares held by OPI VII. OrbiMed Advisors exercises this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of the Shares held by OPI VII. The Reporting Person is a member of OrbiMed Advisors. The Reporting Person disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any such entity or person is a beneficial owner of such securities for purpose of Section 16 of the Exchange Act, or for any other purpose. The option will vest on the first anniversary of the date of grant or, if earlier, the date of Imara's next annual meeting of stockholders following the date of grant. Pursuant to an agreement with OrbiMed Advisors and OrbiMed GP, the Reporting Person is obligated to transfer these securities, or the economic benefit thereof, to OrbiMed Advisors and OrbiMed GP, which will in turn ensure that such securities or economic benefits are provided to OPI VII. /s/ Michael P. Gray, Attorney-in-Fact 2021-06-30