Property and equipment, net (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Property, Plant and Equipment, Net, by Type [Abstract]
Total property and equipment, gross	$ 61,522	$ 53,501
Less: Accumulated Depreciation	(52,307)	(45,668)
Total property and equipment, net	9,215	7,833
Depreciation expense	4,100	5,300	$ 7,600
Leasehold Property Improvements [Member]
Property, Plant and Equipment, Net, by Type [Abstract]
Total property and equipment, gross	20,020	19,095
Laboratory Equipment [Member]
Property, Plant and Equipment, Net, by Type [Abstract]
Total property and equipment, gross	39,534	32,265
Office Equipment and Other Assets [Member]
Property, Plant and Equipment, Net, by Type [Abstract]
Total property and equipment, gross	1,922	1,710
Construction in Progress [Member]
Property, Plant and Equipment, Net, by Type [Abstract]
Total property and equipment, gross	$ 46	$ 431