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Share-based compensation (Tables)
 12 Months Ended
Dec. 31, 2023
Share-based compensation [Abstract]  
Share-based Compensation Expense Recorded in Consolidated Statements of Operations and Comprehensive Loss
The following table shows the total share-based compensation expense recorded in the Consolidated Statements of Operations and Comprehensive Loss (in thousands):

   
2023
    
2022
    
2021
  
R&D
  
$
6,467
    
$
5,311
    
$
5,365
  
Selling, general and administrative
  
$
26,002
    
$
27,577
    
$
43,529
  
Number and Weighted Average Exercise Prices of Share Options Activity
The number and weighted average exercise prices of share options are as follows:

 Number of shares issuable
  
Number of
share options (#)
    
Weighted
average
exercise
price
($)
  
Average
Remaining
Contractual
Term
  
Aggregate
Intrinsic Value
(in thousands)
  
Outstanding at January 1, 2021
    
4,551,359
    
$
17.16
          
Awards granted
    
4,702,027
      
26.56
          
Awards exercised
    
(76,762
)
    
17.01
          
Awards forfeited
    
(290,664
)
    
31.24
          
Awards replaced with options
    
312,500
      
38.72
          
Outstanding at December 31, 2021
    
9,198,460
      
22.31
  
8.5 years
  
$
109,749
  
Awards granted
    
1,507,581
      
27.50
            
Awards exercised
    
(492,163
)
    
19.72
            
Awards forfeited
    
(320,634
)
    
26.41
            
Outstanding at December 31, 2022
    
9,893,244
      
23.10
  
7.9 years
  
$
336,120
  
Awards granted
    
853,863
      
62.57
            
Awards exercised
    
(1,637,303
)
    
20.93
            
Awards forfeited
    
(141,922
)
    
34.78
            
Outstanding at December 31, 2023
    
8,967,882
      
27.06
  
7.1 years
  
$
369,976
  
Exercisable at December 31, 2023
    
5,761,718
    
$
22.26
  
6.7 years
  
$
265,412
  
Assumptions used in Determining Fair Value of Stock Options
Awards granted in the year ended December 31, 2023, 2022 and 2021, have been valued using the Black-Scholes option pricing model. The assumptions used in the models for share options granted during year ended December 31, 2023 2022 and 2021, are as follows:
   
2023
    
2022
    
2021
  
Share price at grant date
  
$
46.48 - $64.53
    
$
24.66 - $46.86
    
$
26.00 - $41.74
  
Exercise price
  
$
46.48 - $64.53
    
$
24.66 - $46.86
    
$
26.00 - $41.74
  
Expected volatility
    
66.7% - 72.05%
 
    
73.02% - 87.81%
 
    
83.88% - 88.76%
 
Expected life (years)
  
5 years
    
4 years - 5 years
    
4 years
  
Risk free rate
    
3.52% - 4.75%
 
    
1.12% - 4.12%
 
    
-0.05% - 0.52%
 
Fair value
  
$
27.77 - $39.02
    
$
15.10 - $29.41
    
$
16.16 - $26.18