<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0001193125-22-034420</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0000059478</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>1</amendmentNo>
      <securitiesClassTitle>Ordinary Shares</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>09/30/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001671927</issuerCik>
        <issuerName>Immunocore Holdings plc</issuerName>
        <issuerCusip>54258D105</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>90 PARK DRIVE</com:street1>
          <com:street2>MILTON PARK</com:street2>
          <com:city>ABINGDON, OXFORDSHIRE</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>OX14 4RY</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(d)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>ELI LILLY &amp; Co</reportingPersonName>
      <citizenshipOrOrganization>IN</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>0.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>0.0</classPercent>
      <typeOfReportingPerson>CO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>

      <reportingPersonName>ELI LILLY S.A.</reportingPersonName>
      <citizenshipOrOrganization>V8</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>0.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <classPercent>0.0</classPercent>
      <typeOfReportingPerson>CO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Immunocore Holdings plc</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>90 PARK DRIVE, MILTON PARK, ABINGDON, OXFORDSHIRE, UNITED KINGDOM, OX14 4RY.</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Eli Lilly S.A.
Eli Lilly and Company</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>c/o Lilly Corporate Center
Indianapolis, Indiana 46285</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Eli Lilly S.A. Switzerland societe anonyme
Eli Lilly and Company Indiana corporation</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>See Item 9 of Cover Sheet.</amountBeneficiallyOwned>
        <classPercent>See Item 11 of Cover Sheet.</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>See Item 5 of Cover Sheet.
</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>See Item 6 of Cover Sheet.
</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>See Item 7 of Cover Sheet.
</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>See Item 8 of Cover Sheet.
</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>Y</notApplicableFlag>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>ELI LILLY &amp; Co</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Christopher Anderson</signature>
        <title>Attorney-in-Fact</title>
        <date>10/03/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>ELI LILLY S.A.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Christopher Anderson</signature>
        <title>Attorney-in-Fact</title>
        <date>10/03/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureComments>This Schedule 13G/A was executed pursuant to a power of attorney for Eli Lilly and Company previously
filed with the Securities and Exchange Commission, and hereby incorporated by reference herein. The
power of attorney was filed as Exhibit 99.3 to a filing on Schedule 13G for the Issuer on February 10,
2022.

This Schedule 13G/A was executed pursuant to a power of attorney for Eli Lilly S.A. previously filed with
the Securities and Exchange Commission, and hereby incorporated by reference herein. The power of
attorney was filed as Exhibit 99.2 to a filing on Schedule 13G for the Issuer on February 10, 2022.</signatureComments>
  </formData>
</edgarSubmission>
