X0306 4 2020-12-31 0 0001652130 Intellia Therapeutics, Inc. NTLA 0001671870 Rivera Jose E C/O INTELLIA THERAPEUTICS, INC. 40 ERIE STREET; SUITE 130 CAMBRIDGE MA 02139 0 1 0 0 EVP, General Counsel Common Stock 2020-12-31 4 M 0 4792 0.00 A 54068 D Common Stock 2021-01-05 4 S 0 2078 55.86 D 51990 D Common Stock 262210 I By Trust Stock Option (right to buy) 23.46 2020-12-31 4 A 0 9583 0.00 A 2020-12-31 2028-03-20 Common Stock 9583 9583 D Restricted Stock Unit (performance-based) 2020-12-31 4 A 0 4792 0.00 A 2020-12-31 Common Stock 4792 4792 D Restricted Stock Unit (performance-based) 2020-12-31 4 M 0 4792 0.00 D 2020-12-31 Common Stock 4792 0 D Includes 568 shares acquired under the Intellia Therapeutics, Inc. 2016 Employee Stock Purchase Plan on December 31, 2020. Shares sold in sell-to-cover transaction in order to satisfy withholding taxes to be paid upon the vesting of 4,792 performance-based restricted stock units ("PRSUs") on December 31, 2020. Shares are held by Rivak Capital LLC ("Rivak"). Mr. Rivera is a member and the general manager of Rivak and has voting and dispositive power over these shares. On March 21, 2018, the reporting person was granted an option to purchase 28,750 shares of common stock pursuant to the Intellia Therapeutics, Inc. Amended and Restated 2015 Stock Option and Incentive Plan. The award had performance-based vesting, with one-third of the award vesting upon each achievement of three scientific and regulatory milestones through the calendar year 2020 (the "Performance Milestones"). On December 31, 2020, one of the Performance Milestones was achieved, resulting in the vesting of the option as to 9,583 shares. On March 21, 2018, the reporting person was granted 14,375 PRSUs pursuant to the Intellia Therapeutics, Inc. Amended and Restated 2015 Stock Option and Incentive Plan. Each PRSU represents a contingent right to receive one share of the Company's common stock upon vesting, with one-third of the PRSUs vesting upon each achievement of the Performance Milestones through the calendar year 2020. On December 31, 2020, one of the Performance Milestones was achieved, resulting in the vesting of 4,792 PRSUs. /s/Jose Rivera 2021-01-05