X0306 4 2020-08-18 0 0001652130 Intellia Therapeutics, Inc. NTLA 0001671870 Rivera Jose E C/O INTELLIA THERAPEUTICS, INC. 40 ERIE STREET; SUITE 130 CAMBRIDGE MA 02139 0 1 0 0 EVP, General Counsel Common Stock 2020-08-18 4 M 0 10000 6.83 A 37524 D Common Stock 2020-08-18 4 S 0 5615 21.00 D 31909 D Common Stock 262210 I See Footnote Stock Option (right to buy) 6.83 2020-08-18 4 M 0 10000 0.00 D 2026-02-02 Common Stock 10000 135117 D The sales reported on this Form 4 were effected pursuant to a trading plan adopted pursuant to Rule 10b5-1 under the Securities Exchange Act of 1934, as amended. Shares are held by Rivak Capital LLC ("Rivak"). Mr. Rivera is a member and the general manager of Rivak and has voting and dispositive power over these shares. The stock option award was issued pursuant to the Intellia Therapeutics, Inc. Amended and Restated 2015 Stock Option and Incentive Plan and vested in full on February 3, 2020. /s/Jose Rivera 2020-08-20