Exhibit 23.1

Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm

We consent to the reference to our firm under the caption “Experts” and to the use of our report dated October 2, 2020, in the Registration Statement (Form S-1) and related Prospectus of Silverback Therapeutics, Inc. for the registration of shares of its common stock.

/s/ Ernst & Young LLP

November 10, 2020