CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Income Statement [Abstract]
Royalty revenue	$ 12,292	$ 4,309
Revenue from Contract with Customer, Product and Service [Extensible List]		us-gaap:RoyaltyMember
Operating expenses:
Research and development	(18,994)	$ (17,852)
General and administrative	(14,698)	(13,951)
Loss from operations	(21,400)	(27,494)
Other expense from continuing operations, net	(8,008)	(1,325)
Loss on extinguishment of debt		(2,104)
Net loss from continuing operations	(29,408)	(30,923)
Discontinued operations:
Income (loss) from discontinued operations	951	13,173
Net loss	$ (28,457)	$ (17,750)
Net loss from continuing operations per share	$ (6.27)	$ (9.12)
Net income from discontinued operations per share	0.20	3.88
Basic and diluted net loss per basic share	$ (6.07)	$ (5.23)
Weighted-average shares used to compute per share calculations	4,687,952	3,390,919