X0306 4 2019-05-29 0 0001446847 IRONWOOD PHARMACEUTICALS INC IRWD 0001670893 Dreyfus Andrew C/O IRONWOOD PHARMACEUTICALS, INC. 301 BINNEY STREET CAMBRIDGE MA 02142 1 0 0 0 Class A Common Stock 2019-05-29 4 A 0 22706 0.00 A 80813 D The restricted stock, granted pursuant to the director compensation policy, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year. /s/ Conor Kilroy, Attorney-in-Fact 2019-05-31