<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001524599</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001668397</issuerCik>
      <issuerName>Medpace Holdings, Inc.</issuerName>
      <secFileNumber>001-37856</secFileNumber>
      <issuerAddress>
        <com:street1>5375 Medpace Way</com:street1>
        <com:city>Cincinnati</com:city>
        <com:stateOrCountry>OH</com:stateOrCountry>
        <com:zipCode>45227</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>513-579-9911</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Medpace Investors, LLC</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Affiliate</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>UBS Financial Services Inc</name>
        <address>
          <com:street1>1000 Harbor Blvd</com:street1>
          <com:street2>3rd Floor</com:street2>
          <com:city>Weehawken</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07086</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>100000</noOfUnitsSold>
      <aggregateMarketValue>41000000</aggregateMarketValue>
      <noOfUnitsOutstanding>30759281</noOfUnitsOutstanding>
      <approxSaleDate>03/07/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>06/11/2011</acquiredDate>
      <natureOfAcquisitionTransaction>Acquired in CCMP acquisition</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>100000</amountOfSecuritiesAcquired>
      <paymentDate>06/11/2011</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Medpace Investors, LLC</name>
        <address>
          <com:street1>5375 Medpace Way</com:street1>
          <com:city>Cincinnati</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>45227</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/16/2024</saleDate>
      <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
      <grossProceeds>19587423</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Medpace Investors, LLC</name>
        <address>
          <com:street1>5375 Medpace Way</com:street1>
          <com:city>Cincinnati</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>45227</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/20/2024</saleDate>
      <amountOfSecuritiesSold>13988</amountOfSecuritiesSold>
      <grossProceeds>5404793</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Medpace Investors, LLC</name>
        <address>
          <com:street1>5375 Medpace Way</com:street1>
          <com:city>Cincinnati</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>45227</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/21/2024</saleDate>
      <amountOfSecuritiesSold>36012</amountOfSecuritiesSold>
      <grossProceeds>13808612</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Medpace Investors, LLC</name>
        <address>
          <com:street1>5375 Medpace Way</com:street1>
          <com:city>Cincinnati</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>45227</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/22/2024</saleDate>
      <amountOfSecuritiesSold>100000</amountOfSecuritiesSold>
      <grossProceeds>39597941</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Medpace Investors, LLC</name>
        <address>
          <com:street1>5375 Medpace Way</com:street1>
          <com:city>Cincinnati</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>45227</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/23/2024</saleDate>
      <amountOfSecuritiesSold>100000</amountOfSecuritiesSold>
      <grossProceeds>40031795</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Medpace Investors, LLC</name>
        <address>
          <com:street1>5375 Medpace Way</com:street1>
          <com:city>Cincinnati</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>45227</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/26/2024</saleDate>
      <amountOfSecuritiesSold>56928</amountOfSecuritiesSold>
      <grossProceeds>22906727</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Medpace Investors, LLC</name>
        <address>
          <com:street1>5375 Medpace Way</com:street1>
          <com:city>Cincinnati</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>45227</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/27/2024</saleDate>
      <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
      <grossProceeds>20094187</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Medpace Investors, LLC</name>
        <address>
          <com:street1>5375 Medpace Way</com:street1>
          <com:city>Cincinnati</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>45227</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/28/2024</saleDate>
      <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
      <grossProceeds>20206277</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Medpace Investors, LLC</name>
        <address>
          <com:street1>5375 Medpace Way</com:street1>
          <com:city>Cincinnati</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>45227</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/29/2024</saleDate>
      <amountOfSecuritiesSold>20000</amountOfSecuritiesSold>
      <grossProceeds>7874236</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Medpace Investors, LLC</name>
        <address>
          <com:street1>5375 Medpace Way</com:street1>
          <com:city>Cincinnati</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>45227</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/01/2024</saleDate>
      <amountOfSecuritiesSold>80000</amountOfSecuritiesSold>
      <grossProceeds>32150477</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Medpace Investors, LLC</name>
        <address>
          <com:street1>5375 Medpace Way</com:street1>
          <com:city>Cincinnati</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>45227</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/04/2024</saleDate>
      <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
      <grossProceeds>20156173</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Medpace Investors, LLC</name>
        <address>
          <com:street1>5375 Medpace Way</com:street1>
          <com:city>Cincinnati</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>45227</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/05/2024</saleDate>
      <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
      <grossProceeds>20134876</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Medpace Investors, LLC</name>
        <address>
          <com:street1>5375 Medpace Way</com:street1>
          <com:city>Cincinnati</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>45227</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/06/2024</saleDate>
      <amountOfSecuritiesSold>100000</amountOfSecuritiesSold>
      <grossProceeds>41297784</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>03/07/2024</noticeDate>
      <signature>/s/ UBS Financial Services Inc, as attorney-in-fact for Medpace Investors, LLC</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
