X0306 4 2021-12-23 0 0001668397 Medpace Holdings, Inc. MEDP 0001524599 Medpace Investors, LLC C/O MEDPACE HOLDINGS, INC. 5375 MEDPACE WAY CINCINNATI OH 45227 0 0 1 0 Common Stock 2021-12-23 4 S 0 22830 223.19 D 5616585 D Common Stock 2021-12-27 4 S 0 39171 226.11 D 5577414 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 1, 2021. The reported price is a weighted average price. These shares were sold in multiple transactions ranging from $219.94 to $224.68. The Reporting Person undertakes to provide full pricing information to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission upon request. The reported price is a weighted average price. These shares were sold in multiple transactions ranging from $223.28 to $227.87. The Reporting Person undertakes to provide full pricing information to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission upon request. /s/ Stephen P. Ewald, Authorized Signatory for Medpace Investors, LLC 2021-12-28