X0306 4 2021-04-14 0 0001668397 Medpace Holdings, Inc. MEDP 0001677297 EWALD STEPHEN P C/O MEDPACE HOLDINGS, INC. 5375 MEDPACE WAY CINCINNATI OH 45227 0 1 0 0 General Counsel & Corp. Secy. Common Stock 2021-04-14 4 M 0 1200 28.32 A 15054 D Common Stock 2021-04-14 4 S 0 1200 180.67 D 13854 D Common Stock 2021-04-15 4 M 0 3800 28.32 A 17654 D Common Stock 2021-04-15 4 S 0 3800 185.18 D 13854 D Employee Stock Option (Right to Buy) 28.32 2021-04-14 4 M 0 1200 0.00 D 2021-03-15 2024-03-15 Common Stock 1200 3800 D Employee Stock Option (Right to Buy) 28.32 2021-04-15 4 M 0 3800 0.00 D 2021-03-15 2024-03-15 Common Stock 3800 0 D The sales reported on this Form 4 were effected pursuant to a limit order placed by the Reporting Person during an open window period. The reported price is a weighted average price. These shares were sold in multiple transactions ranging from $180.11 to $181.28. The Reporting Person undertakes to provide full pricing information to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission upon request. The reported price is a weighted average price. These shares were sold in multiple transactions ranging from $181.13 to $187.07. The Reporting Person undertakes to provide full pricing information to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission upon request. Each option vested on March 15, 2021. /s/ Stephen P. Ewald 2021-04-16