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Share-Based Compensation - Additional Information (Details) - USD ($)
$ / shares in Units, $ in Millions
1 Months Ended 3 Months Ended
Jan. 03, 2019
Jan. 02, 2019
Oct. 12, 2018
Jan. 01, 2018
Mar. 31, 2017
Mar. 31, 2019
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]            
Awards vesting period           1 year
Unrecognized compensation cost of options and RSUs           $ 63.2
Expected to be recognized over a weighted average period           2 years 4 months 24 days
Options | Board Of Directors            
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]            
Grants related option awards   $ 3.4        
Options | Elizabeth Barrett            
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]            
Option to purchase of ordinary shares 277,432          
Exercise price of option to purchase of ordinary shares $ 47.57          
Options | General and Administrative and Research and Development Expenses | Board Of Directors            
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]            
Estimated fair value of options granted   $ 2.8        
Options | Tranche One            
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]            
Vesting percentage           33.00%
Restricted Stock Units (RSUs)            
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]            
Awards vesting period           2 years
Restricted Stock Units (RSUs) | Elizabeth Barrett            
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]            
Option to purchase of ordinary shares 317,065          
Restricted Stock Units (RSUs) | Tranche One            
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]            
Vesting percentage           33.00%
2017 Equity Incentive Plan            
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]            
Maximum number of ordinary share issuable under the 2017 incentive plan         1,400,000 5,600,000
Number of ordinary shares reserved for issuance, percentage           12.00%
Increase in number of ordinary share issuable under the 2017 incentive plan     1,900,000 250,167    
Stock Options and Restricted Stock Units (RSUs) | Elizabeth Barrett            
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]            
Fair value $ 24.1          
Plan | Options            
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]            
Awards vesting period           3 years
Combined voting power percentage           10.00%
Ordinary Shares | 2017 Equity Incentive Plan            
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]            
Maximum number of ordinary share issuable under the 2017 incentive plan     3,550,167 1,650,167    
Maximum | Plan | Options            
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]            
Options granted, expected term           10 years
Minimum | Plan | Options            
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]            
Exercise price of stock options as percentage of fair market value of shares on grant date           100.00%
Stock options exercise price percentage for individuals possesses more than 10% of the combined voter power           110.00%