X0508 4 2025-11-19 0001668243 UroGen Pharma Ltd. URGN 0001763581 Schoenberg Mark 400 ALEXANDER PARK DRIVE PRINCETON NJ 08540 1 Chief Medical Officer 1 Ordinary Shares 2025-11-19 4 S 0 10000 25 D 139025 D Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c). Adoption date of referenced 10b5-1(c) plan is: 08-15-2025. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.00 and $25.02. The reporting person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range. /s/ Jason D. Smith, Attorney-in-Fact 2025-11-20