X0508 4 2025-01-31 0001668243 UroGen Pharma Ltd. URGN 0001821479 Smith Jason Drew 400 ALEXANDER PARK DRIVE PRINCETON NJ 08540 1 General Counsel 0 Ordinary Shares 2025-01-31 4 M 0 2500 A 27726 D Ordinary Shares 2025-01-31 4 S 0 1258 11.14 D 26468 D Ordinary Shares 2025-01-31 4 M 0 6667 A 33135 D Ordinary Shares 2025-01-31 4 S 0 3354 11.14 D 29781 D Ordinary Shares 2025-01-31 4 M 0 5500 A 35281 D Ordinary Shares 2025-01-31 4 S 0 2767 11.14 D 32514 D Restricted Stock Units 2025-01-31 4 M 0 2500 0 D Ordinary Shares 2500 0 D Restricted Stock Units 2025-01-31 4 M 0 6667 0 D Ordinary Shares 6667 6667 D Restricted Stock Units 2025-01-31 4 M 0 5500 0 D Ordinary Shares 5500 11000 D Restricted Stock Units 2025-01-31 4 A 0 10000 0 A Ordinary Shares 10000 10000 D Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer. Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units. The reporting person was granted RSUs on January 31, 2022 representing 7,500 ordinary shares. The RSUs will vest in three equal annual installments from January 31, 2023. The reporting person was granted RSUs on January 31, 2023 representing 20,000 ordinary shares. The RSUs will vest in three equal annual installments from January 31, 2024. The reporting person was granted RSUs on January 31, 2024 representing 16,500 ordinary shares. The RSUs will vest in three equal annual installments from January 31, 2025. 1/3 of the shares underlying the restricted stock units will vest on each of January 31, 2026, January 31, 2027 and January 31, 2028. /s/ Jason D. Smith, Attorney-in-Fact 2025-02-04