X0306 4 2022-01-31 0 0001668243 UroGen Pharma Ltd. URGN 0001764157 Barrett Elizabeth A. 400 ALEXANDER PARK DRIVE PRINCETON NJ 08540 0 1 0 0 Chief Executive Officer Ordinary Shares 2022-01-31 4 M 0 5000 A 303220 D Ordinary Shares 2022-01-31 4 S 0 2235 7.58 D 300985 D Ordinary Shares 2022-01-31 4 M 0 13333 A 314318 D Ordinary Shares 2022-01-31 4 S 0 5960 7.58 D 308358 D Restricted Stock Units 2022-01-31 4 M 0 5000 0.00 D Ordinary Shares 5000 5000 D Restricted Stock Units 2022-01-31 4 M 0 13333 0.00 D Ordinary Shares 13333 26667 D Stock Option (right to buy) 7.72 2022-01-31 4 A 0 150000 0.00 A 2032-01-31 Ordinary Shares 150000 150000 D Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units The reporting person was granted restricted stock units ("RSUs") on January 31, 2020 representing 15,000 ordinary shares. The RSUs vest in three equal annual installments from January 31, 2021. The reporting person was granted restricted stock units ("RSUs") on January 31, 2021 representing 40,000 ordinary shares. The RSUs vest in three equal annual installments from January 31, 2022. 1/3 of the shares underlying the stock options will vest on each of January 31, 2023, January 31, 2024 and January 31, 2025 /s/ Jason Smith, Attorney-in-Fact 2022-02-01