X0306 4 2022-01-03 0 0001668243 UroGen Pharma Ltd. URGN 0001764157 Barrett Elizabeth A. 400 ALEXANDER PARK DRIVE PRINCETON NJ 08540 0 1 0 0 Chief Executive Officer Ordinary Shares 2022-01-03 4 M 0 105689 A 345188 D Ordinary Shares 2022-01-04 4 S 0 46968 9.15 D 298220 D Restricted Stock Units 2022-01-03 4 M 0 105689 0.00 D Ordinary Shares 105689 0 D Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units The reporting person was granted RSUs on January 3, 2019 representing 317,065 ordinary shares. 33.33% of the RSUs vested on January 3, 2020. 33.33% of the RSUs vested in equal monthly installments through January 3, 2021. The remaining 33.33% of the RSUs vested on January 3, 2022. /s/ Jason Smith, Attorney-in-Fact 2022-01-06