X0306 4 2020-10-15 1 0001668243 UroGen Pharma Ltd. URGN 0001585839 PFREUNDSCHUH PETER P. 400 ALEXANDER PARK DRIVE PRINCETON NJ 08540 0 1 0 0 Chief Financial Officer Ordinary Shares 2020-10-15 4 M 0 4917 A 12805 D Ordinary Shares 2020-10-15 4 S 0 976 21.7992 D 11829 D Ordinary Shares 2020-10-15 4 S 0 407 21.8243 D 11422 D Ordinary Shares 2020-10-15 4 S 0 1017 21.72 D 10405 D Restricted Stock Units 2020-10-15 4 M 0 833 0.00 D Ordinary Shares 833 1667 D Restricted Stock Units 2020-10-15 4 M 0 2084 0.00 D Ordinary Shares 2084 2082 D Restricted Stock Units 2020-10-15 4 M 0 2000 0.00 D Ordinary Shares 2000 4000 D Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer. Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units. The reporting person was granted restricted stock units ("RSUs") on January 26, 2019 representing 5,000 ordinary shares. 33.33% of the RSUs vested on January 26, 2020 and 8.33% of the remaining RSUs vest in equal quarterly installments thereafter. In September the award was modified to accelerate vesting at October 15, 2020 for amounts of RSUs that would have otherwise become vested as of April 15, 2021. The reporting person was granted restricted stock units ("RSUs") on August 20, 2018 representing 5,000 ordinary shares. 33.33% of the RSUs vested on August 20, 2019 and 8.33% of the remaining RSUs vest in equal quarterly installments thereafter. In September the award was modified to accelerate vesting at October 15, 2020 for amounts of RSUs that would have otherwise become vested as of April 15, 2021. The reporting person was granted restricted stock units ("RSUs") on January 31, 2020 representing 5,000 ordinary shares. Under the original terms of the agreement, 33.33% of the RSUs will vest on January 31, 2021 and 8.33% of the remaining RSUs vest in equal quarterly installments thereafter. In September the award was modified to accelerate vesting at October 15, 2020 for amounts of RSUs that would have otherwise become vested as of April 15, 2021. /s/ Jason Smith, Attorney-in-Fact 2020-10-16