X0306 4 2019-02-06 0 0001668243 UroGen Pharma Ltd. URGN 0001339358 Cohen Fred E C/O UROGEN PHARMA LTD. 9 HA?TA?ASIYA STREET RA?ANANA L3 4365007 ISRAEL 1 0 0 0 Ordinary Shares 2019-02-06 4 M 0 15000 16.99 A 15000 D Stock Option (Right to Buy) 16.99 2019-02-06 4 M 0 15000 0.00 D 2027-05-15 Ordinary Shares 15000 25000 D 6.25% of the ordinary shares underlying the stock option vested on each of August 15, 2017, November 15, 2017 and February 15, 2018; 31.25% of the shares vested on May 15, 2018, and the remaining shares vest in 8 equal quarterly installments thereafter. /s/ Peter Pfreundschuh, Attorney-in-Fact 2019-03-20