X0306 4 2019-01-26 0 0001668243 UroGen Pharma Ltd. URGN 0001585839 PFREUNDSCHUH PETER P. C/O UROGEN PHARMA LTD. 9 HA?TA?ASIYA STREET RA?ANANA L3 4365007 ISRAEL 0 1 0 0 Chief Financial Officer Employee Stock Option (right to buy) 42.50 2019-01-26 4 A 0 15000 0.00 A 2029-01-26 Ordinary Shares 15000 15000 D Restricted Stock Unit 2019-01-26 4 A 0 5000 0.00 A Ordinary Shares 5000 5000 D 33.33% of the shares underlying the stock option will vest on January 26, 2020 and 12.5% of the remaining shares will vest in eight equal quarterly installments thereafter. Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock. 33.33% of the RSUs will vest on January 26, 2020 and 12.5% of the remaining RSUs will vest in eight equal quarterly installments thereafter. /s/ Peter Pfreundschuh, Attorney-in-Fact 2019-01-29