X0407 4 2022-06-15 0 0001616543 Senseonics Holdings, Inc. SENS 0001667593 JAIN Mukul 20451 SENECA MEADOWS PARKWAY GERMANTOWN MD 20876-7005 0 1 0 0 Chief Operating Officer 0 Common Stock 2022-06-15 4 F 0 38018 0.97 D 2468138 D Common Stock 2022-11-15 4 F 0 185273 1.25 D 2282865 D Common Stock 2023-05-15 4 F 0 217479 0.74 D 2065386 D Common Stock 2023-05-15 4 A 0 1380157 0.00 A 3445543 D Represents shares withheld to satisfy withholding tax obligations upon the vesting of restricted stock units ("RSUs"). Represents an RSU grant. The RSUs vest in eight equal installments with the first installment vesting on June 15, 2023 and the remaining seven installments vesting in six month increments commencing on November 15, 2023, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date. Each RSU represents a contingent right to receive one share of the Issuer's common stock. The Form 4 filed by the reporting person on August 5, 2022 is deemed amended hereby to give effect to the transaction effected on June 15, 2022 reported herein. /s/ Darren K. DeStefano, Attorney-in-Fact 2023-05-17