X0306 4 2022-05-26 0 0001616543 Senseonics Holdings, Inc. SENS 0001667593 JAIN Mukul 20451 SENECA MEADOWS PARKWAY GERMANTOWN MD 20876-7005 0 1 0 0 Chief Operating Officer Common Stock 2022-05-26 4 A 0 45000 0.00 A 1780293 D Common Stock 2022-05-26 4 A 0 775863 0.00 A 2556156 D Represents a Restricted Stock Unit ("RSU") grant. The RSUs vest on May 15, 2023, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date. Each RSU represents a contingent right to receive one share of the Issuer's common stock. Represents an RSU grant. The RSUs vest in eight equal installments with the first installment vesting on June 15, 2022 and the remaining seven installments vesting in six month increments commencing on November 15, 2022, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date /s/ Darren K. DeStefano, Attorney-in-Fact 2022-05-31