X0306 4 2020-11-15 0 0001616543 Senseonics Holdings, Inc. SENS 0001667588 Goodnow Timothy T 20451 SENECA MEADOWS PARKWAY GERMANTOWN MD 20876-7005 1 1 0 0 President and CEO Common Stock 2020-11-15 4 F 0 155511 0.39 D 3962421 D Common Stock 2021-05-15 4 F 0 231007 1.92 D 3731414 D Common Stock 2021-05-25 4 A 0 1099462 0.00 A 4830876 D Represents shares withheld to satisfy withholding tax obligations upon the vesting of restricted stock units ("RSUs"). Represents a RSU grant. The RSUs vest in eight equal installments with the first installment vesting on June 15, 2021 and the remaining RSUs vesting in six month increments commencing on November 15, 2021, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date. Each RSU represents a contingent right to receive one share of the Issuer's common stock. /s/ Darren K. DeStefano, Attorney-in-Fact 2021-05-27