X0306 4 2017-05-24 0 0001616543 Senseonics Holdings, Inc. SENS 0001666995 Prince Douglas S 20451 SENECA MEADOWS PARKWAY GERMANTOWN MD 20876-7005 1 0 0 0 Stock Option (right to buy) 1.35 2017-05-24 4 A 0 128817 0.00 A 2027-05-23 Common Stock 128817 128817 D The exercise price is equal to the closing price of the Issuer's common stock on the NYSE-MKT on the date of grant, May 24, 2017. This grant was made as compensation for the reporting person's service on the Issuer's board of directors. Under the Issuer's non-employee director compensation policy, each non-employee director who continues to serve as a member of the Issuer's board of directors is eligible to receive an annual stock option grant following each annual meeting of the Issuer's stockholders. The number of shares underlying the option is equal to a Black Scholes option value of $106,500. The shares underlying the option will vest in full on the one year anniversary of the date of grant, subject to the reporting person's continuous service through the vesting date. /s/ Darren K. DeStefano, Attorney-in-fact 2017-05-26