X0306 4 2022-03-11 0 0001616543 Senseonics Holdings, Inc. SENS 0001666972 Fiorentino Edward 20451 SENECA MEADOWS PARKWAY GERMANTOWN MD 20876-7005 1 0 0 0 Common Stock 2022-03-11 4 M 0 83900 0.54 A 491292 D Common Stock 2022-03-11 4 S 0 63553 1.65 D 427739 D Stock Option (right to buy) 0.54 2022-03-11 4 M 0 83900 0.00 D 2022-03-14 Common Stock 83900 0 D Represents the exercise of a stock option held by the Reporting Person that was scheduled to expire, if not exercised, on March 14, 2022. Represents the required number of shares sold to satisfy the exercise price of the expiring option and the Reporting Person's tax obligations resulting from the exercise. Beyond this required number of shares, no additional shares were sold by the Reporting Person. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.65 to $1.67 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Immediately exercisable. /s/ Darren K. DeStefano, Attorney-in-Fact 2022-03-15