X0306 4 2020-07-20 0 0001616543 Senseonics Holdings, Inc. SENS 0001666972 Fiorentino Edward 20451 SENECA MEADOWS PARKWAY GERMANTOWN MD 20876-7005 1 0 0 0 Common Stock 2020-07-20 4 A 0 273077 0.00 A 391477 D Represents a restricted stock unit ("RSU") grant. The RSUs vest in eight equal installments with the first installment vesting on July 21, 2020 and the remaining RSUs vesting in six month increments commencing on November 15, 2020, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date. Each RSU represents a contingent right to receive one share of the Issuer's common stock. /s/ Mark Ballantyne, Attorney-in-Fact 2020-07-22