X0306 4 2022-08-12 0 0001582313 Xenon Pharmaceuticals Inc. XENE 0001665430 EMPFIELD JAMES R. 200 - 3650 GILMORE WAY BURNABY A1 V5G 4W8 BRITISH COLUMBIA, CANADA 0 1 0 0 EVP, Drug Discovery Common Shares 2022-08-12 4 M 0 20000 3.10 A 30000 D Common Shares 2022-08-12 4 M 0 45000 4.75 A 75000 D Common Shares 2022-08-12 4 F 0 7257 38.02 D 67743 D Common Shares 2022-08-12 4 S 0 35868 38.08 D 31875 D Common Shares 2022-08-12 4 S 0 21875 38.68 D 10000 D Stock Option (Right to Buy) 3.10 2022-08-12 4 M 0 20000 0.00 D 2027-10-22 Common Shares 20000 0 D Stock Option (Right to Buy) 4.75 2022-08-12 4 M 0 45000 0.00 D 2028-03-11 Common Shares 45000 0 D Represents the closing price of the Company's common shares on August 11, 2022 for purposes of net settlement calculations. The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $37.5101 to $38.5029, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. The "Amount" and "Price" reported in this Column 4 reflect the aggregate number and weighted-average price, respectively, of shares sold. These shares were sold in multiple transactions at prices ranging from $38.6084 to $38.7884, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein. The shares subject to the option are fully vested and exercisable. /s/ Cassandra Robinson, Attorney-in-fact 2022-08-16